American Journal of Clinical Nutrition, 2010, 91(3):722-8.

Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan

Taichi Shimazu, Manami Inoue, et al

Japan Public Health Center–based Prospective Study Group

Background: Although case-control studies support the idea that soy foods or isoflavone intake is associated with a decreased risk of lung cancer, little evidence is available from prospective cohort studies. Moreover, no prospective study has addressed this association in men.

Objective: We investigated the association between isoflavone intake and lung cancer incidence.

Design: We conducted a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999. Participants responded to a validated questionnaire, which included 138 food items. We used Cox proportional hazards regression analysis to estimate the hazard ratios (HRs) and 95% CIs of lung cancer incidence according to isoflavone intake, which was estimated by genistein content from soy foods.

Results: During 11 y (671,864 person-years) of follow-up, we documented 481 male and 178 female lung cancer cases. In men we found an inverse association between isoflavone intake and risk of lung cancer in never smokers (n = 13,051; multivariate HR in the highest compared with the lowest quartile of isoflavone intake: 0.43; 95% CI: 0.21, 0.90; P for trend = 0.024) but not in current or past smokers. A similar, nonsignificant inverse association was seen in never-smoking women (n = 38,211; HR: 0.67; 95% CI: 0.41, 1.10; P for trend = 0.135). We also tested effect modification by smoking status (P for interaction = 0.085 in men and 0.055 in men and women combined).

Conclusion: In a large-scale, population-based, prospective study in Japan, isoflavone intake was associated with a decreased risk of lung cancer in never smokers.

美国《美国临床营养学杂志》2010年1月

摄入异黄酮与罹患肺癌的风险︰ 一项在日本的前瞻性研究

岛津太极，井上奈美等

日本公共卫生中心前瞻性研究团队

背景︰ 虽然病例-对照的研究支持大豆食品或大豆异黄酮的摄入量与肺癌风险降低有关的观点，但是在前瞻性研究中几乎没有证据是可用的。此外，没有哪个前瞻性研究致力于证明关联存在于男性中。

目的︰ 研究大豆异黄酮的摄入量和肺癌发病率之间的关联。

设计︰ 我们对年龄在45-74岁并且在 1995-1999 年期间没有癌症病史的36,177 名男性和 40,484 名女性进行了基于人口的前瞻性研究。被调查者填写了一份包括 138 种食品的有效问卷。我们利用 Cox 比例风险回归分析来估计危险比率 (HRs) 和依照异黄酮的摄入量（由大豆食品中的金雀异黄素的含量评估）计算 95%CIs的肺癌发病率。

结果︰ 在 11 年（671,864 人） 的后续行动中，我们记录了 481名 男性和 178名女性的肺癌病例。在男性中我们发现在从未吸烟者而不是目前或过去的吸烟者中存在异黄酮摄取量和肺癌风险之间的逆关联 (n = 13,051; 多元HR最高与最低四分位数的异黄酮摄取量相比:0.43; 95%CI: 0.21, 0.90; P = 0.024)。一个类似的、 无足轻重的逆关联同样存在于从不吸烟的女性中 (n = 38,211;HR: 0.67;95%CI: 0.41, 1.10; P = 0.135)。我们还在修正吸烟状况的情况下进行了测试 (相互 P =男性 0.085以及男性和女性共同0.055)。