Leukemia Research, 2010, 34(34):69-76

GCP, a genistein-rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines

Jamie L. McCall, Rebekah A. Burich, Philip C. Mack

Division of Hematology/Oncology, Department of Internal Medicine, University of California, Davis Cancer Center, Sacramento, CA, USA

Genistein combined polysaccharide (GCP), derived from soy bean extract, is comprised of deglycosylated isoflavones, such as genistein and daidzein. The goal of this work was to determine if GCP is effective in lymphoid cancers.

In three human and four canine lymphoid cell lines, GCP inhibited proliferation and induced G2/M arrest. Additionally, increased apoptosis was observed in Ramos and Jurkat lines. These results demonstrate that GCP is effective in lymphoid cell lines of both human and canine origin. Due to its minimal toxicities, increased bioavailability, and in vitro efficacy, GCP may have clinical utility in the treatment of patients with lymphoma.

英国《白血病研究》，2010年

GCP，一种富含染料木素的化合物，可以抑制淋巴瘤细胞株的增殖并且诱导其凋亡

杰米 L麦考尔，利百加 A 里奇，菲利普 C马克

美国加利福尼亚大学内科血液学/肿瘤学部

来自大豆提取物，结合多糖的金雀异黄素(GCP)，由分离的大豆异黄酮，如染料木素和大豆黄酮等组成。这项工作的目标是确定 GCP是否对淋巴肿瘤有效。

在三个人和四条狗的淋巴细胞系中，GCP可以 抑制细胞增殖，并诱导 G2/M 期阻滞。此外，在拉莫斯和白血病细胞系中观察到凋亡有所增加。这些结果表明，GCP 对于人和狗的淋巴细胞系是有效的。由于其最小的毒副反应，提高的生物利用度以及体外功效，GCP 可能对淋巴瘤患者具有临床实用的疗效。