Archives of Dermatological Research, 2010, 302(2):71-83.

Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms

Joi A. Nichols, Santosh K. Katiyar

Department of Dermatology, University of Alabama at Birmingham, Birmingham; Birmingham Veterans Administration Medical Center, Birmingham; et al

Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including premature aging of the skin and melanoma and nonmelanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc.. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse, or retard the process of these harmful events in the UV-exposed skin. A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, oxidative stress, and DNA damage, etc., with a focus on mechanisms underlying the photoprotective effects of these polyphenols. The laboratory studies conducted in animal models, suggest that these polyphenols have the ability to protect the skin from the adverse effects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA  damage.

德国《皮肤病研究档案》，2010年

天然多酚类物质对皮肤的光保护作用︰ 抗炎、 抗氧化以及 DNA 修复机制

乔伊 A尼科尔斯，桑托斯 K.卡缇娅

伯明翰阿拉巴马大学皮肤科，伯明翰退伍军人医学管理中心等

流行病学，临床和实验室研究均证明紫外线 (UV) 辐射与多种皮肤疾病有关，包括黑素瘤和非黑色素皮肤癌症的过早老化。慢性紫外线辐射暴露引起的皮肤疾病是由于炎症的过度诱导、 氧化应激和 DNA 损伤等造成的。使用化学防护药剂如植物多酚等来抑制紫外线暴露导致的皮肤疾病越来越被关注。化学预防指的是使用可以抑制、 逆转或者延缓紫外线伤害暴露皮肤的发展过程的药物。种类繁多的多酚或者植物化学物质，大部分是膳食补充剂，被报道具有坚固的皮肤光保护作用。本综述总结了一些选定的多酚类物质，如绿茶茶多酚、 葡萄籽原花青素、 白藜芦醇、 水飞蓟素和金雀异黄素对紫外线诱导皮肤炎症、 氧化应激和 DNA 损伤等的光保护作用，重点放在这些多酚类发挥光保护作用的机制。实验室对动物模型的研究证明这些多酚类物质有能力保护皮肤免受紫外线辐射的危害，包括皮肤患癌的风险。建议多酚可以被首先添加到保护性防晒霜中，以及可用于治疗与紫外光辐射诱导炎症、 氧化应激和 DNA 损伤等相关的皮肤疾病。