Nutrition & Cancer, 2010, 62(8):1036-43.

Effects of a High Dose, Aglycone-Rich Soy Extract on Prostate-Specific Antigen and Serum Isoflavone Concentrations in Men With Localized Prostate Cancer

Ralph W. deVere White, Alexander Tsodikov, et al

University of California, Davis , Sacramento, California, USA; Amino Up Chemical Company, Ltd. , Sapporo, Japan; et al

The efficacy and safety of consuming high-dose isoflavone supplements for prostate cancer is not clear. A double-blind, placebo controlled, randomized trial was conducted in 53 men with prostate cancer enrolled in an active surveillance program. The treatment group consumed a supplement containing 450 mg genistein, 300 mg daidzein, and other isoflavones daily for 6 mo. Prostate-specific antigen (PSA) was measured in both groups at baseline, 3 mo, and 6 mo, and serum concentrations of genistein, daidzein, and equol were assessed at baseline and 6 mo in the treatment group. Following the completion of the 6-mo double-blind study, men were enrolled in a 6-mo open label trial with the same isoflavone-rich supplement, and PSA was measured at 3 and 6 mo. PSA concentrations did not change in either group after 6 mo or after 12 mo when the open-label study was included. The 6 mo serum concentrations of genistein and daidzein (39.85 and 45.59 μmol/l, respectively) were significantly greater than baseline values and substantially higher than levels previously reported in other studies. Equol levels did not change. Although high amounts of aglycone isoflavones may result in significantly elevated serum concentrations of genistein and daidzein, these dietary supplements alone did not lower PSA levels in men with low-volume prostate cancer.

美国《营养和癌症》，2010年11月

高剂量，富含苷元的大豆提取物对局部前列腺癌患者的前列腺特异性抗原和血清异黄酮浓度的作用

拉尔夫 W 德维尔 怀特，亚历山大 措季科夫等

美国加利福尼亚大学戴维斯分校，日本阿明诺化学有限公司等

高剂量异黄酮补充剂对前列腺癌的有效性和安全性尚不清楚。53名前列腺癌患者参与的积极监测程序进行了双盲、 空白对照和随机试验。治疗组在6个月中每天消耗一份含有450 mg染料木黄酮，300 mg大豆黄酮和其他异黄酮的补充剂。在0、 3 个月和 6 个月分别测定前列腺特异性抗原 (PSA)，并且评估0和 6 个月染料木素、 大豆甙元、 和雌马酚的血清浓度。在6个月的双盲研究完成以后，男性又参加了6 个月的开放性实验并且食用富含异黄酮的相同补充剂，然后分别在3个月和6个月测定PSA。当开放性试验被列入时，在6 个月或 12 个月后两组的PSA 浓度并没有改变。第6 个月染料木素和大豆黄酮的血清浓度(39.85 和 45.59 umol/L，分别) 都明显大于第0个月，并且大幅度高于先前其他研究中报道的水平。雌马酚的水平没有变化。虽然大量的大豆异黄酮苷元可能导致染料木素和大豆黄酮血清浓度的显著升高，这些单独的膳食补充剂并没有降低小体积前列腺癌患者的 PSA 水平。