Nutrition & Cancer, 2010, 62(6):765-73.

Effect of dietary intake of isoflavones on the estrogen and progesterone receptor status of breast cancer

Min Zhang, Xiaojiao Liu, et al

School of Population Health, The University of Western Australia , Perth, Western Australia, Australia; et al

To examine if higher intake of isoflavones prior to diagnosis was associated with a positive status of estrogen receptors (ER) and progesterone receptors (PR) in breast tumor tissue, a retrospective study was conducted in 2004 to 2005 in 756 Chinese women with histologically confirmed breast cancer. We administered a food frequency questionnaire by face-to-face interview to assess the intake of the isoflavones daidzein and genistein. Unconditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for potential confounders. Comparing the highest to lowest intake quartiles, the adjusted ORs for daidzein were 1.94 (95% CI = 1.20-3.32) and 2.18 (95% CI = 1.28-3.73) for ER positive and PR positive tumors, respectively, in premenopausal patients. The ORs for both ER and PR positive status combined were 2.48 (95% CI = 1.37-4.49) for daidzein and 1.94 (95% CI = 1.21-3.14) for genistein in premenopausal patients with statistically significant tests for trend. There was little or no evidence of associations in postmenopausal patients. We conclude that higher intake of daidzein and genistein before diagnosis was associated with ER and PR positive status in premenopausal Chinese women with breast cancer. The association might confer a more favorable prognosis.

美国《营养和癌症》，2010年

异黄酮的膳食摄入量对乳腺癌雌激素和孕激素受体状态的影响

张敏，刘晓娇等

澳大利亚西澳大利亚大学人体健康学院等

为了测试在诊断前更高摄入量的异黄酮是否与雌激素受体 (ER)和 孕激素受体 (PR) 在乳腺肿瘤组织的积极状态有关系，在 2004年-2005 年选择了756名 中国乳腺癌女性患者进行了一项回顾性研究。我们进行了一张面对面访问的食物频率调查问卷，从而评估摄入的异黄酮大豆苷元和染料木黄酮。非条件性log回归分析被用于计算比值 (ORs) 和为了潜在混杂因素 调控的95%可信区间 （独联体） 。比较最高和最低的摄入四分位数，对于绝经前患者，大豆苷元调整后的Ors对于ER 阳性肿瘤和 PR 阳性肿瘤分别是 1.94 (95 % CI= 1.20-3.32) 和 2.18 (95 % CI = 1.28-3.73)。对于绝经前患者来说，ER和PR 的阳性结合状态的ORs值是大豆苷元2.48 (95 % CI= 1.37-4.49) 大豆苷元和染料木黄酮 1.94 (95 % CI = 1.21-3.14)。在绝经后患者中很少或没有证据证明这些关系。我们得出结论，在诊断前高摄入大豆苷元和染料木黄酮与中国绝经前乳腺癌患者的ER、 PR 阳性相关联。这一关系可能赋予更好的预后。