Seminars in Cutaneous Medicine & Surgery, 2011, 30(1):6-13.

New Agents for Prevention of Ultraviolet-Induced Nonmelanoma Skin Cancer

William L. Camp, et al

Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL; et al

With the incidence of nonmelanoma skin cancer on the rise, current prevention methods, such as the use of sunscreens, have yet to prove adequate to reverse this trend. There has been considerable interest in identifying compounds that will inhibit or reverse the biochemical changes required for skin cancers to develop, either by pharmacologic intervention or by dietary manipulation. By targeting different pathways identified as important in the pathogenesis of nonmelanoma skin cancers, a combination approach with multiple agents or the addition of chemopreventative agents to topical sunscreens may offer the potential for novel and synergistic therapies in treating nonmelanoma skin cancer.

美国《皮肤医学与外科手术研讨会》，2011年3月

用于预防紫外线诱导的非黑色素皮肤癌的新试剂

威廉 L 坎普等

英国伯明翰阿拉巴马大学伯明翰分校皮肤科等

随着皮肤癌的发病率逐渐增加，当前的预防方法，例如使用防晒霜，尚未被证明足以扭转这一趋势。人们对通过药物干预或膳食控制确认可以抑制或扭转皮肤癌症发展的化合物产生相当大的兴趣。针对不同已被确定为重要的皮肤癌发病机制的路径，一种将多种试剂或化学防护性试剂添加到防晒霜中的联合方法可能提供了潜在的治疗皮肤癌新型和协同疗法。