Nutrition & Cancer, 2011, 63(2):161-73.

Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

Muthu K Shanmugam, Radhamani Kannaiyan, Gautam Sethi

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Cancer is one of the leading causes of death in the United States and around the world. Most modern drug-targeted therapies, besides being enormously expensive, are associated with serious side effects and morbidity. Still, the search continues for an ideal treatment that has minimal side effects and is cost-effective. Indeed, the design and development of chemopreventive agents that act on specific and/or multiple molecular and cellular targets is gaining support as a rational approach to prevent and treat cancer. We present evidence on numerous dietary agents identified from fruits and vegetables that act on multiple signal transduction and apoptotic cascades in various tumor cells and animal models. Some of the most interesting and well documented are turmeric (curcumin), resveratrol, silymarin, EGCG, and genistein. This review will provide an insight on the cellular and molecular mechanism(s) by which dietary agents modulate multiple signaling and apoptotic pathways in tumor cells and elucidate the role of these agents in both prevention and treatment of cancer.

美国《营养与癌症》，2011年2月

针对细胞信号转导和凋亡通路的膳食试剂︰ 在预防和治疗癌症中的作用

木都 K 尚穆加姆，拉曼妮 康奈亚， 塔姆 塞西

新加坡国立大学医学院药理系

在美国和世界各地范围内癌症是死亡的主要原因之一。最现代的药物靶向疗法，除了成本极高，与严重的副作用和发病率。然而，仍在搜索一种理想的副作用最小，有成本效益的治疗方法。事实上，根据特定和/或多个分子和细胞靶点的化学预防试剂的开发与设计作为一种合理的方法来预防和治疗癌症获得支持。我们目前确定了从水果和蔬菜等提取的多种饮食试剂可以作用于各种肿瘤细胞和动物模型中的多个信号转导和细胞凋亡通路。一些最有吸引力的和有据可查的是郁金香 （姜黄）、 白藜芦醇、 水飞蓟素，EGCG，和染料木黄酮。本综述将提供对膳食试剂调节多种信号和凋亡通路的细胞和分子机制的了解，并且阐明这些药物在预防和治疗癌症方面的作用。