Molecular Nutrition & Food Research, 2011, 55(1):122–135.

Dietary supplements and human health: For better or for worse?

Jerome-Morais Anita, Alan M. Diamond, Margaret E. Wright

Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA

Encouraged by the potential health benefits of higher dietary intake of substances with beneficial properties, the use of supplements containing these compounds has increased steadily over recent years. The effects of several of these, many of which are antioxidants, have been supported by data obtained in vitro, in animal models, and often by human studies as well. However, as carefully controlled human supplementation trials have been conducted, questions about the efficacy and safety of these supplements have emerged. In this Educational Paper, three different supplements were selected for consideration of the benefits and risks currently associated with their intake. The selected supplements include β-carotene, selenium, and genistein. The use of each is discussed in the context of preclinical and clinical data that provide evidence for both their use in reducing disease incidence and the possible liabilities that accompany their enhanced consumption. Variables that may influence their impact, such as lifestyle habits, baseline nutritional levels, and genetic makeup are considered and the application of these issues to broader classes of supplements is discussed.

德国《分子营养与食品研究》，2011年1月

膳食补充剂和人类健康︰ 更好或更坏吗？

杰罗姆 莫雷斯 安妮塔，艾伦 M 戴蒙德，玛格丽特 E怀特

美国伊利诺伊大学病理学系

受到具有潜在有益健康性质的较高饮食摄取量的鼓舞，对含有这些化合物补充剂的使用近年来稳定增长。其中几种大多是抗氧化剂的影响，通常由体外，动物模型中，以及人体研究的数据支持。然而，虽然严格控制了人体补充剂实验，但是有关这些补充剂疗效和安全性的问题出现。在这篇教育性文献中，选择三种不同的补充剂考察与摄入量有关的效益和风险。所选的补充剂包括 β-胡萝卜素、 硒和金雀异黄素。在临床前和临床数据中讨论了每种补充剂在减少疾病发生率的作用以及消耗的增多导致可能的倾向。考虑可能会影响它们作用的变量，如生活习惯、 基线营养水平和基因组成的变量等并讨论了如何使更多种类补充剂得到应用。