J Tradit Complement Med, 2012, 2(2):96-104.

Genistein as a Potential Anticancer Agent against Ovarian Cancer

Jung Yun Lee, Hee Seung Kim, Yong Sang Song

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea; et al

Genistein is known as the major component of isoflavone, which is present in high-soy diets. Genistein has received much attention because of its chemopreventive and therapeutic effects on various types of cancers. Numerous studies have shown that genistein has antineoplastic effects against ovarian cancer. Several epidemiological studies have shown that women who have high consumption of isoflavones have a relatively low incidence of ovarian cancer. Genistein inhibits ovarian carcinogenesis by pleiotropic mechanisms. A higher affinity to estrogen receptor β is one probable explanation for its ability to reduce the risk of ovarian cancer. Genistein also targets multiple cellular signal transduction pathways associated with cell cycle regulation and apoptosis. In addition, genistein has been suggested to have antiangiogenic and antioxidant activities. Herein, we summarize recent results from epidemiological and experimental studies to identify the role of genistein in ovarian cancer. Further studies are needed to achieve conclusive results and determine the clinical applications of genistein.

《传统互补医学杂志》，2012年4月

金雀异黄素作为一种治疗卵巢癌潜在的抗癌试剂

李荣云，金汉师，宋永松

韩国首尔大学医学院妇产科等

已知金雀异黄素是异黄酮的主要成分，存在于高浓度大豆饮食中。金雀异黄素由于其对各种类型癌症的化学预防和治疗的作用受到众多关注。许多研究表明，染料木黄酮具有抗卵巢癌的作用。一些流行病学研究显示大量摄取异黄酮的女性卵巢癌的发病率较低。金雀异黄素通过多效机制抑制卵巢癌变。对雌激素受体 β较高的亲和力可能是其能够减少卵巢癌风险的一个原因。金雀异黄素还将目标指向多种与细胞周期调控和细胞凋亡有关的细胞信号转导通路。此外，金雀异黄素具有抗血管生成和抗氧化的活性。这里，我们总结了最近流行病学和实验研究的结果，以确定金雀异黄素在卵巢癌中的作用。还需要进一步的研究得到决定性的结果，并确定金雀异黄素的临床应用。