Oxidative Medicine & Cellular Longevity, 2012, 2012(3):202-220.

Polyphenols: Key Issues Involved in Chemoprevention of Prostate Cancer

Sebastiano Cimino, Giuseppe Sortino, Vincenzo Favilla, et al

Department of Urology, University of Catania, 95125 Catania, Italy; et al

Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable preneoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer. This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein. Although the current studies are limited, mechanisms of action of polyphenols added with the lack of side effects show a a start for future strategies in prostate chemoprevention.

美国《氧化医学 和 细胞寿命》，2012年5月

多酚：参与前列腺癌化学预防作用的关键问题

塞巴斯蒂亚诺 米洛，约瑟佩  索尔蒂诺，文森佐 付伟拉，等

意大利卡塔尼亚大学泌尿外科等

前列腺癌是最常见的固体肿瘤，现在被视为男性面临的最重要的医疗问题之一。由于其长时间的潜伏期和可识别的病前病变，前列腺癌是一种理想的化学预防靶向肿瘤。不同的可用化合物和某些多酚具有对前列腺癌的疗效。本综述考察了主要的多酚类物质的活性和特性，例如儿茶素-3-没食子酸、 姜黄、 白藜芦醇及黄酮类化合物槲皮素和金雀异黄素等。虽然目前的研究有限，没有副作用的多酚的作用机制对于前列腺化学预防的未来战略是一个开始。