Journal of Agricultural & Food Chemistry, 2013, 61(8):1878-83.

Curcumin and Genistein Coloaded Nanostructured Lipid Carriers: in Vitro Digestion and Antiprostate Cancer Activity

N. P. Aditya, Myeongkuk Shim, Inae Lee, et al

Department of Food Science and Technology, Sejong University, Seoul, Republic of Korea; et al

To increase the oral bioavailability of curcumin and genistein, we fabricated nanostructured lipid carriers (NLCs), and the impact of these carriers on bioaccessibility of curcumin and genistein was studied. Entrapment efficiency was more than 75% for curcumin and/or genistein-loaded NLCs. Solubility of curcumin and/or genistein in simulated intestinal medium (SIM) was >75% after encapsulating within NLCs which otherwise was <20%. Both curcumin and genistein have shown good stability (≥85%) in SIM and simulated gastric medium (SGM) up to 6 h. Coloading of curcumin and genistein had no adverse effect on solubility and stability of each molecule. Instead, coloading increased loading efficiency and the cell growth inhibition in prostate cancer cells. Collectively, these results have shown that coloaded lipid based carriers are promising vehicles for oral delivery of poorly bioaccessible molecules like curcumin and genistein.

美国《农业与食品化学学报》，2013年2月

纳米脂质载体共负载的姜黄素和金雀异黄素︰ 在体外的消化和抗前列腺癌活性

阿迪蒂亚N.P.，塞姆 米用库克，李音，等

韩国首尔世宗大学部的食品科学与技术学院等

为了增加姜黄色素和金雀异黄素的口服生物利用度，我们制造了纳米脂质载体 (NLCs)，并且研究了这些载体对姜黄色素和金雀异黄素的生物可给性的影响。姜黄素和 （或）金雀异黄素负载NLCs的包封率超过75%。在封装以后姜黄素和/或金雀异黄素在模拟肠液(SIM)中的溶解度> 75%，否则只有 < 20%。直到6 h姜黄素和金雀异黄素在 SIM和模拟胃介质 (SGM) 中表现出良好的稳定性 （≥ 85%）。姜黄色素和金雀异黄素的共负载对每个分子的溶解性和稳定性没有任何不良影响。相反，共负载提高了负载率和对前列腺癌细胞生长的抑制。总之，这些结果表明共负载脂质基载体对于生物利用度差的分子如姜黄色素和金雀异黄素的口服给药有前途。