Anticancer Research, 2013, 33(1):39-44.

Genistein and Daidzein: Different Molecular Effects on Prostate Cancer

Jean-Paul Boiteux, et al

Department of Oncogenetics, Jean Perrin Center, 58 rue Montalembert, 63000 Clermont-Ferrand Cedex 01, France; et al

Diet is believed to play an important role in cancer. It has been revealed by epidemiological studies that Asian populations, who consume phytoestrogens in large amounts, have a lower incidence of prostate cancer in comparison with the Western world, where consumption of soy is lower. Genistein and daidzein, the soy phytoestrogens most widely studied, are believed to be potent anticancer agents and have been shown to possess anticancer properties. It has been shown that these compounds inhibit the growth of cancer cells through the modulation of genes controlling cell-cycle progression. Genistein inhibits the activation of the kappa light polypeptide gene enhancer in B-cells (NF-κB), signaling pathway, which is implicated in the balance between cell survival and programmed cell death (apoptosis). Antioxidant and antiangiogenesis properties of genistein have been also described. Soy isoflavones are also implicated in reversion of epigenetic events observed in prostate cancer. Significant advances have been made for understanding how soy isoflavones are implicated in protection against prostate cancer. However, more studies are needed to better-understand and elucidate all pathways mobilized by genistein and daidzein, in order to fully exploit their anticancer properties.

希腊《抗癌研究》，2013年1月

金雀异黄素和大豆黄酮︰对前列腺癌的不同分子作用

约翰 保罗 布瓦德，等

法国让佩林中心成瘤部等

饮食被认为在癌症中发挥重要的作用。流行病学研究显示消耗大量植物雌激素的亚洲人群，前列腺癌的发病率较低，与大豆消费较低的西方世界相比。金雀异黄素和大豆苷元，大豆植物雌激素中被最广泛研究，被证明是有效的抗癌药物并且具有抗癌特性。结果表明这些化合物通过调节基因控制的细胞周期进程抑制肿瘤细胞的生长。金雀异黄素抑制 kappa 轻多肽基因增强因子在 B 细胞中的活化 (NF-κ B)，信号转导通路，与细胞存活和细胞程序性的死亡 （凋亡） 之间的平衡有关。此外介绍了金雀异黄素的抗氧化和抗血管生成属性。大豆异黄酮也与在前列腺癌中观察到的表观遗传逆转有关系。了解大豆异黄酮如何介入对前列腺癌的保护已取得了重大进展。然而，需要更多的研究，以更好地了解和确认金雀异黄素和大豆黄酮调节色所有途径，为了充分利用其抗癌特性。