The AAPS Journal, 2013, 15(4):991-1000.

Perspectives on the Role of Isoflavones in Prostate Cancer

Aamir Ahmad, Bernhard Biersack, Yiwei Li, et al

Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 HWCRC Bldg, 4100 John R. Street, Detroit, Michigan, 48201,USA; et al

Isoflavones have been investigated in detail for their role in the prevention and therapy of prostate cancer. This is primarily because of the overwhelming data connecting high dietary isoflavone intake with reduced risk of developing prostate cancer. A number of investigations have evaluated the mechanism(s) of anticancer action of isoflavones such as genistein, daidzein, biochanin A, equol, etc., in various prostate cancer models, both in vitro and in vivo. Genistein quickly jumped to the forefront of isoflavone cancer research, but the initial enthusiasm was followed by reports on its contradictory prometastatic and tumor-promoting effects. Use of soy isoflavone mixture has been advocated as an alternative, wherein daidzein can negate harmful effects of genistein. Recent research indicates a novel role of genistein and other isoflavones in the potentiation of radiation therapy, epigenetic regulation of key tumor suppressors and oncogenes, and the modulation of miRNAs, epithelial-to-mesenchymal transition, and cancer stem cells, which has renewed the interest of cancer researchers in this class of anticancer compounds. This comprehensive review article summarizes our current understanding of the role of isoflavones in prostate cancer research.

美国《美国药物科学家杂志》，2013年10月

异黄酮对前列腺癌作用的展望

艾哈迈德 阿米尔，博赛克 伯恩哈德，李一伟，等

美国底特律韦恩州立医科大学卡马诺斯癌症研究所病理部等

详细研究了异黄酮在预防和治疗前列腺癌中的作用。这主要是因为绝大多数的数据与膳食异黄酮的摄入量高与患前列腺癌的风险降低有关。大量的研究评估异黄酮例如金雀异黄素、 大豆苷元、 鹰嘴豆芽素A，雌马酚等，在各种前列腺癌模型中，体内和体外抗肿瘤作用的机制。金雀异黄素迅速地跳到了异黄酮癌症研究的最前沿，但在最初的热情之后关于其转移和肿瘤促进的矛盾作用被报道。使用大豆异黄酮混合物作为替代物，其中大豆黄酮可以抵消金雀异黄素的有害影响。最近的研究表明金雀异黄素和其他异黄酮在放射治疗时程、关键肿瘤抑制因子和癌基因的表观遗传调控，和miRNAs的调控, 皮-间充质转变和癌症干细胞等方面的新作用，这重新燃起了研究人员对此类抗癌化合物的兴趣。本综述总结了目前我们对异黄酮在前列腺癌研究中的作用的了解。