Nutrition & Cancer, 2013, 65(3):390-7.

Population Versus Hospital Controls in the Assessment of Dietary Intake of Isoflavone for Case-Control Studies on Cancers in China

Lin Li, Min Zhang, C D'Arcy J Holman

School of Population Health, The University of Western Australia, Crawley, WA, Australia

To assess dietary isoflavone intake between population and hospital outpatient controls and examine if cancer risks estimated for isoflavone using hospital outpatient controls would be different from those using population controls. Three parallel case-control studies on leukemia, breast, and colorectal cancers in China in 2009-2010 were conducted, using population and hospital outpatient controls to separately match 560 incident cases at a 1:1 ratio. A validated food frequency questionnaire was administered by face-to-face interview. Conditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). The 2 control groups had closely similar distributions of dietary isoflavone intake. Risk estimates for breast cancers were adjusted ORs (95% CI) of 0.39 (0.23-0.66) and 0.31 (0.18-0.55) for daidzein, 0.35 (0.20-0.61) and 0.28 (0.16-0.52) for genistein, 0.66 (0.41-1.08) and 0.53 (0.32-0.88) for glycitein, and 0.53 (0.33-0.85) and 0.43 (0.26-0.71) for total isoflavone using hospital outpatient and population controls respectively. The study found that hospital outpatient controls were comparable to population controls in measured dietary intake of isoflavone in the Chinese hospital setting.

美国《营养与癌症》，2013年3月

评估中国的大豆异黄酮的摄入量作为癌症的病例-对照研究时对比人群与医院的对照病例

李琳，张敏，C  达奇 J 霍尔曼

澳大利亚西方大学人体健康学院

为了评估人口与医院门诊病人对照样之间的膳食异黄酮摄取量并测试使用医院门诊病人对照样与人口对照样的癌症风险是否不一样。对中国 2009年-2010 年的三个平行病例白血病、 乳腺癌和直肠癌进行对照研究，使用人口与医院门诊病人对照样以1:1 的比例分别匹配 560 件病例。一份明确的食物频率问卷被用来面对面的采访。有条件对数回归分析被用于计算优势比 (ORs) 和 95%的可信区间 （CIs）。2个 对照组有非常相似的膳食异黄酮摄取量分布。乳腺癌的风险评估被调节了ORs(95 %CI)，大豆苷元0.39 (0.23-0.66)和 0.31 (0.18-0.55)、金雀异黄素0.35 (0.20-0.61) 和 0.28 (0.16-0.52)，黄豆黄素0.66 (0.41-1.08) 和 0.53 (0.32-0.88)，和总异黄酮的0.53 (0.33-0.85) 和 0.43 (0.26-0.71)， 分别使用医院门诊病人和人口对照样。研究发现，对于中国医院大豆异黄酮的膳食摄入量，医院门诊病人比得上人口对照样。