Nutrition Reviews, 2013, 71(9):585-99.

Dietary phytochemicals in cancer prevention and therapy: a complementary approach with promising perspectives

Margarita González-Vallinas, Marta González-Castejón, Arantxa Rodríguez-Casado, et al

IMDEA-Food Institute, Madrid, Spain

The population is aging. Over the coming years, the incidence of age-related chronic diseases such as cancer is expected to continue to increase. Phytochemicals, which are non-nutritive chemicals found in plants and food, have emerged as modulators of key cellular signaling pathways exerting proven anticancer effects. The challenge now is to develop personalized supplements comprised of specific phytochemicals for each clinical situation. This will be possible once a better understanding is gained of the molecular basis explaining the impact of phytochemicals on human health. The aim of the present literature review is to summarize current knowledge of the dietary phytochemicals with proven antitumor activity, with a special emphasis placed on their molecular targets. Also discussed are the limits of existing research strategies and the future directions of this field.

美国《营养综述》，2013年9月

用于癌症预防和治疗的饮食植物化学成分︰ 一种前景广阔的补充方法

玛格丽塔  冈萨雷斯 威廉纳斯，玛尔塔  冈萨雷斯 洪德，阿阮特萨 罗德里格斯  卡萨，等

西班牙马德里IMDEA 食品研究所

人口正在老龄化。未来几年内，与年龄有关的慢性疾病例如癌症等的发病率预计将继续增加。植物化学物质，在植物和食物中发现的非营养性化学成分，已成为证明抗癌作用的关键细胞信号通路的调节剂。当前的挑战是开发由特定植物组成的针对每个临床情况的个性化补充剂。对揭示了植物化学物质对人类健康影响的分子基础得到更好的理解，是非常可能的。目前的文献综述的目的是总结膳食植物化学物质以及经过验证的抗肿瘤活性的当前知识，其重点放在分子靶标上。此外讨论了现有研究方法的限制和这一领域未来的方向。