Nutrition Reviews, 2013, 71(8):562–572.

Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases

Syed F Zafar, et al

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA

Genistein is a soy-derived biologically active isoflavone that exhibits diverse health-promoting effects. An increasing body of evidence shows that genistein influences lipid homeostasis and insulin resistance, counteracts inflammatory cytokines, and possesses antidiabetic properties. Genistein also impedes cancer progression by promoting apoptosis, inducing cell cycle arrest, modulating intracellular signaling pathways, and inhibiting angiogenesis and metastasis of neoplastic cells. This review summarizes the pleiotropic functions of genistein in common health disorders such as metabolic syndrome, chronic inflammatory diseases, and cancer. In the current era of uncontrolled health expenditure, a focus on the clinical development of nutritional agents with the capacity to prevent a variety of common health disorders is needed. As a micronutrient that exerts multifaceted effects ranging from antidiabetic to anticarcinogenic functions, genistein should be clinically developed further for use in the prevention and treatment of a variety of health disorders.

美国《营养综述》，2013年8月

金雀异黄素对代谢、 炎症和恶性疾病的多效作用

赛义德  F  扎法尔，等

美国佐治亚州亚特兰大埃默里大学温希普癌症研究所肿瘤和医学肿瘤科

金雀异黄素是一种大豆衍生的生物活性异黄酮，表现出多样的健康促进作用。越来越多的证据显示，金雀异黄素影响脂质代谢和胰岛素抗性、 抵消炎性细胞因子，并且具有抗糖尿病属性。金雀异黄素也会通过促进细胞凋亡、 诱导细胞周期阻滞、 调节细胞内信号转导通路阻碍癌症的进展，抑制血管生成与肿瘤细胞转移。本文综述了金雀异黄素对代谢综合征、 慢性炎症性疾病和癌症等常见疾病的多效性功能。在当今这个健康不受控制的时代，需要重点关注能够预防各种常见健康疾病的营养药物的临床发展。作为在抗糖尿病到抗癌等发面发挥多效作用的营养素，金雀异黄素应被进一步临床开发用于预防和治疗各种健康疾病。