Prostate Cancer Prevention. Springer Berlin Heidelberg, 2014:101-108.

Chemoprevention of Prostate Cancer by Isoflavonoids

Stefan Aufderklamm, Florian Miller, Anastasia Galasso, et al

Department of Urology, Eberhard-Karls University, Tübingen, Germany; et al

In Europe, prostate cancer (PC) is the most common malignancy in males. There are three known risk factors strongly coherent to the development of PC: heredity, ethnical origin, and age. Migration studies have shown that environmental factors may influence the development of PC. In this context, specific nutritional components may exert an influence on the tumorigenesis of PC. Primary prevention of PC is still an important issue due to its high prevalence, treatment-associated morbidities, and long-term complications. Phytoestrogenes as flavonoids seem to play an essential role in the chemoprevention of PC which is possibly due to their hormonal function and antioxidative capability. Flavonoids and their subgroups are naturally existent in traditional asian and vegetarian nutrients as coverings of plants, fruits, and vegetables. Two of the most frequently investigated flavonoids are genistein and quercetin. These nutritional components may have therapeutic potential and may impact the development of PC. Even though these flavonoids show promising results in the chemoprevention of PC, the literature is almost experimental, epidemiological, and retrospective with a missing long-term follow-up. Therefore, randomized clinical trials are urgently needed to evaluate in depth its oncologic effects in PC.

《前列腺癌预防》，2014年2月

异黄酮类化合物对前列腺癌的化学预防

史蒂芬 奥弗德克拉曼，弗洛里安 米勒，阿纳斯塔西亚 加拉索，等

德国埃伯哈德-卡尔斯大学泌尿外科；等

在欧洲，前列腺癌 (PC) 是男性最常见的恶性肿瘤。已知的与 PC 发展强烈相关的危险因素有三个︰ 遗传、 种族起源和年龄。移民研究表明，环境因素可能会影响 PC 的发展。在这种情况下，特定的营养成分可能会影响 PC 的癌变进程。因其高发病率、治疗期间产生相关疾病和长期的并发症，PC的初期预防仍然是一个重要的问题。黄酮类化合物作为植物雌激素看起来在化学预防PC方面发挥着至关重要的作用，可能是由于它们的激素功能和抗氧化能力。黄酮类化合物和它们的子群天然存在于传统的亚洲素食营养物如植物、 水果和蔬菜。其中两个最广泛研究的黄酮类化合物是金雀异黄素和槲皮素。这些营养成分可能具有治疗的潜力，可能会影响 PC 的发展。即使这些黄酮类化合物在 PC 的化学治疗中展示了可喜的成果，文章所涉及的也是实验、 流行病学、 和缺少长期随访的回访。因此，迫切需要随机临床试验来深入评估 PC 及其肿瘤效应。