Cell Proliferation, 2014, 47(6):506–515.

Plant natural products: from traditional compounds to new emerging drugs in cancer therapy

L. Ouyang, Y. Luo, M. Tian, et al

State Key Laboratory of Biotherapy and Department of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China

Natural products are chemical compounds or substances produced naturally by living organisms. With the development of modern technology, more and more plant extracts have been found to be useful to medical practice. Both micromolecules and macromolecules have been reported to have the ability to inhibit tumour progression, a novel weapon to fight cancer by targeting its 10 characteristic hallmarks. In this review, we focus on summarizing plant natural compounds and their derivatives with anti-tumour properties, into categories, according to their potential therapeutic strategies against different types of human cancer. Taken together, we present a well-grounded review of these properties, hoping to shed new light on discovery of novel anti-tumour therapeutic drugs from known plant natural sources.

英国《细胞增殖》，2014年12月

植物天然产物︰ 在肿瘤治疗中从传统化合物到新兴药物

欧阳L，罗Y，田M，等

中国四川成都四川大学华西医院生物治疗国家重点实验室与泌尿外科

天然产物是一种化学化合物或者由活的生物体自然产生的物质。随着现代科技的发展，越来越多的植物提取物被发现对医疗有作用。小分子和大分子均被报道过有能力抑制肿瘤的进展。针对肿瘤的 10 个特征标志，出现了一种新式武器以对抗癌症。在本综述中，我们专注于总结具有抗肿瘤性质的植物天然化合物及其衍生物，并根据它们对不同类型人体癌症的潜在治疗策略分类。综上所述，我们展示了对这些属性的充分总结，希望从已知的植物天然来源中发现新型抗肿瘤治疗药物。