Respiratory Medicine, 2014, 30(4):143-50.

Chemopreventive and chemotherapeutic effects of genistein, a soy isoflavone, upon cancer development and progression in preclinical animal models

Seung-Hee Kim, Cho-Won Kim, So-Ye Jeon, et al

Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea

Genistein is one of isoflavones mostly derived in a leguminous plant. It is well known as one of phytoestrogens that have structures similar to the principal mammalian estrogen. It has diverse biological functions including chemopreventive properties against cancers. Anticancer efficacies of genistein have been related with the epidemiological observations indicating that the incidence of some cancers is much lower in Asia, where diets are rich in soyfoods, than Western countries. This review deals with in vivo anticancer activities of genistein identified in animal studies being divided into its effects on carcinogenesis and cancer progression. Because animal studies have advantages in designing the experiments to suit the goals, they imply diverse information on the anticancer activity of genistein. The in vivo animal studies have adopted the specific animal models according to a developmental stage of cancer to prove the anticancer efficacies of genistein against diverse types of cancer. The numerous previous studies insist that genistein effectively inhibits carcinogenesis in the DMBA-induced animal cancer models by reducing the incidence of adenocarcinoma and cancer progression in the transgenic and xenograft animal models by suppressing the tumor growth and metastatic transition. Although the protective effect of genistein against cancer has been controversial, genistein may be a candidate for chemoprevention of carcinogenesis and cancer progression and may deserve to be the central compound supporting the epidemiological evidence.

英国《呼吸内科》，2014年12月

在诱发癌症并发展的临床动物模型中，一种大豆异黄酮，金雀异黄素的化学预防和治疗作用

金承熙、金光光，钱索业，等

韩国忠北国立大学兽医学院生化和免疫学实验室

金雀异黄素是一种异黄酮，大多来源于一种豆科植物。已知它是一种植物雌激素，结构类似于主要哺乳动物的雌激素。它具有不同的生物学功能，包括对癌症的化学预防属性。将金雀异黄素的抗癌功效与与流行病学观察联系起来发现在亚洲一些癌症的发病率要比西方国家的低得多，是因为那里的饮食中富含豆制品。本综述解决在动物研究中确认金雀异黄素的体内抗肿瘤活性，被划分为对癌变和癌症进展的效用。因为动物研究在设计适合目标的试验方面具有优势，它们表明了金雀异黄素抗癌活性的各种信息。动物体内的研究有特定的动物模型，根据癌症的发展阶段来证明金雀异黄素对不同类型癌症的抗癌疗效。以前的诸多研究认为在DMBA 诱导的动物肿瘤模型中金雀异黄素通过减少腺癌发生率和癌症进展能有效地阻止癌变，而在转基因和异种移植动物模型中则通过抑制肿瘤的生长和转移。虽然金雀异黄素对癌症的保护作用一直存在争议，但是金雀异黄素可能是化学预防癌变和癌症发展的选择，并且可能应该得到重要的流行病学证据。