European Journal of Cancer Prevention the Official Journal of the European Cancer Prevention Organisation, 2015, 24(6).

Flavonoids in oral cancer prevention and therapy

Daniele Maggioni, Luisa Biffi, Gabriella Nicolini, et al

Departments of aSurgery and Translational Medicine bOtorhinolaryngology, Head and Neck Surgery, San Gerardo Hospital, University of Milan-Bicocca, Monza, Italy

Oral cancer, representing all the malignancies arising in the oral cavity, is the eighth most diffused neoplasm worldwide. Despite therapeutic improvements, its survival rate has not changed significantly over the past few decades, with a 5-year survival rate slightly above 50%. In this context, a search for new therapeutic strategies is mandatory. Flavonoids, polyphenolic compounds derived from plants, have a broad spectrum of biological activities, including antioxidant and anticancer. They have been proved to counteract the growth of several types of cancer through multiple mechanisms including the inhibition of cell cycle progression, apoptosis induction, and the modulation of intracellular pathways. Because of their multiple biological activities and their safe toxicological profile, flavonoids have been studied widely in the last decade as potential leads for anticancer therapy. Several studies have reported different flavonoid effects according to cancer cell type. In the present review, therefore, we have evaluated the data available on the effect of flavonoids on oral cancer, with the aim of identifying the molecular mechanisms underlying their potential anticancer properties.

英国《欧洲癌症防治杂志》，2015年

类黄酮在口腔癌预防和治疗中的应用
丹尼勒 麦琪，露萨 比佛，盖博瑞勒 尼克里尼，等
手术和翻译医学部门耳鼻咽喉科，头颈外科，意大利蒙扎米兰 - 比科卡大学圣赫拉多医院

代表口腔中所有恶性肿瘤的口腔癌是全球第八大扩散性肿瘤。尽管治疗改善，其生存率在过去几十年没有显着变化，5年生存率略高于50％。在这种情况下，寻求新的治疗策略是强制性的。类黄酮，衍生自植物的多酚化合物具有广谱的生物活性，包括抗氧化剂和抗癌剂。已被证明通过多种机制来抑制几种类型的癌症的生长，包括抑制细胞周期进程，细胞凋亡诱导和胞内途径的调节。由于其多种生物活性及其安全的毒理学特征，过去十年间，黄酮类化合物广泛应用于抗癌治疗的潜在潜力。根据癌细胞类型，有几项研究报道了不同的​​类黄酮作用。因此，在本次审查中，我们已经评估了有关黄酮类化合物对口腔癌的影响的数据，目的是确定其潜在抗癌性质的基础。