Journal of Oncology Pharmacy Practice Official Publication of the International Society of Oncology Pharmacy Practitioners, 2015, 21(2):128-31.

Soy food frequency questionnaire does not correlate with baseline isoflavone levels in patients with bladder cancer

Jill M Kolesar, Marcia Pomplun, et al

School of Pharmacy, University of Wisconsin, Madison, WI, USA; et al

Background

 The isoflavone genistein, a natural soy product with receptor tyrosine kinase-inhibiting activity, as well as phytoestrogenic and other potential anticarcinogenic effects, is being studied as an anticancer agent. Since isoflavones are commonly consumed in food products containing soy proteins, a method to control for baseline isoflavone consumption is needed.

Methods

HPLC was used to evaluate baseline plasma and urine concentrations of isoflavone in fifty-four participants with bladder cancer enrolled on a phase II chemoprevention study of G-2535. The soy food frequency questionnaire was used to assess participant’s baseline soy intake. The association between baseline isoflavone concentrations and intakes for genistein and daidzein was assessed by the Spearman’s rank correlation coefficient.

Results

The majority of participants had no detectable genistein or daidzein in plasma at baseline. The median and range of values were 0 (0–1480) nmol/L for genistein, and 0 (0–1260) nmol/L for daidzein. In urine, the median and range of values were 91.0 (0–9030) nmol/L for genistein and 623 (0–100,000) nmol/L for daidzein. The median and range of weekly estimated genistein intake was 0 (0–236) mg/wk; the median and range of weekly estimated daidzein intake was 0 (0–114) mg/wk. There was no relationship to soy intake as measured by the food frequency questionnaire and baseline isoflavone levels in plasma or urine and the Spearman’s rank correlation coefficients were not significant.

Conclusion The soy food frequency questionnaire did not correlate with plasma or urine concentrations of either isoflavone.

Impact Alternative methods for controlling for soy consumption, including measuring plasma and urine concentrations, in isoflavone chemoprevention trials should be considered.

英国《肿瘤学药学实践杂志》，2015年4月

大豆食物频率性问卷调查与膀胱移行细胞癌患者的异黄酮水平基线不相关

吉欧 M 克莱萨，麦瑞克 保姆普伦，等

美国威斯康星麦迪逊分校威斯康星大学药学院; 等

背景

  具有受体酪氨酸激酶抑制活性的天然大豆产品以及植物雌激素和其他潜在的致癌作用的异黄酮金雀异黄素正被研究为抗癌剂。 由于异黄酮通常在含有大豆蛋白的食品中被消耗，因此需要一种控制异黄酮消费基线的方法。

方法

使用HPLC评估参与G-2535 II期化学预防研究的五十四名膀胱癌参与者中异黄酮的基线血浆和尿液浓度。 大豆食物频率问卷用于评估参与者的基准大豆摄入量。 基线异黄酮浓度与金雀异黄素和黄豆苷原摄入量之间的关系用斯派尔曼等级相关系数进行评估。

结果

大多数参与者在基线时血浆中没有可检测到的金雀异黄素或黄豆苷元。 金雀异黄素的中值和范围为0（0-1480）nmol / L，黄豆苷原为0（0-1260）nmol / L。 在尿液中，金雀异黄素的中位数和范围值分别为91.0（0-9030）nmol / L，黄豆苷元含量为623（0-100,000）nmol / L。估计每周金雀异黄素摄入量的中值和范围为0（0-236）mg / wk; 估计每周大豆苷原摄入量的中位数和范围为0（0-114）mg / wk。 通过食物频率问卷和血浆或尿液中基线异黄酮水平测量，发现与大豆摄入量无关，并且斯皮尔曼等级相关系数不明显。