在患有无症状的前列腺癌患者食用标准大豆和大豆-杏仁面包以后异黄酮的药代动力学和药物代谢_詹妮弗

针对病种：前列腺癌

发表时间：2015年

发表国家：美国

登载刊物：癌症研究

研究单位：美国俄亥俄州哥伦布市俄亥俄州立大学食品农业与环境科学学院食品科学与技术系

研究人员：詹妮弗安-扎维斯，斯蒂文克林顿，等

主要结论：本研究的结果提供了研究异黄酮代谢表型的必要框架，作为使用膳食大豆可能有益于或显示抗癌预防策略的个体的鉴定策略。用于未来大规模随机临床试验影响人前列腺癌发生的标准化SB是可行的.

Cancer Research, 2015, 73(8):1552-1552.

Isoflavone Pharmacokinetics and Metabolism after Consumption of a Standardized Soy and Soy–Almond Bread in Men with Asymptomatic Prostate Cancer

Jennifer Ahn-Jarvis, Steven Clinton , et al

Department of Food Science and Technology, College of Food, Agricultural, and Environmental Sciences, The Ohio State University, Columbus, Ohio

Epidemiologic associations suggest that populations consuming substantial amounts of dietary soy exhibit a lower risk of prostate cancer. A 20-week randomized, phase II, crossover trial was conducted in 32 men with asymptomatic prostate cancer. The crossover involved 8 weeks each of soy bread (SB) and soy-almond bread (SAB). The primary objective was to investigate isoflavone bioavailability and metabolite profile. Secondary objectives include safety, compliance, and assessment of biomarkers linked to prostate carcinogenesis. Two distinct SBs were formulated to deliver approximately 60 mg aglycone equivalents of isoflavones per day. The isoflavones were present as aglycones (∼78% as aglycones) in the SAB whereas in the standard SB predominantly as glucosides (18% total isoflavones as aglycones). Compliance to SB (97% ± 4%) and SAB (92% ± 18%) was excellent; toxicity was rare and limited to grade 1 gastrointestinal complaints. Pharmacokinetic studies between SB and SAB showed modest differences. Peak serum concentration time (Tmax) was significantly faster with SAB meal compared with SB in some isoflavonoids, and AUC0 to 24 h of dihydrodaidzein and O-desmethylangolensin was significantly greater after an SB meal. An exploratory cluster analysis was used to identify four isoflavone-metabolizing phenotypes. Insulin-like growth factor-binding protein increased significantly by 41% (P = 0.024) with soy intervention. Findings from this study provide the necessary framework to study isoflavone-metabolizing phenotypes as a strategy for identification of individuals that might benefit or show resistance to cancer preventive strategies using dietary soy. A standardized SB used for future large-scale randomized clinical trials to affect human prostate carcinogenesis is feasible.

美国《癌症研究》

在患有无症状的前列腺癌患者食用标准大豆和大豆-杏仁面包以后异黄酮的药代动力学和药物代谢

詹妮弗安-扎维斯，斯蒂文克林顿，等

美国俄亥俄州哥伦布市俄亥俄州立大学食品农业与环境科学学院食品科学与技术系

流行病学协会表明，消费大量膳食大豆的人群表现出较低的前列腺癌风险。在32名无症状前列腺癌男性中进行了为期20周的随机II期跨越试验。其中包括8周的大豆面包（SB）和大豆杏仁面包（SAB）。主要目的是调查异黄酮的生物利用度和代谢物分布。次要目标包括与前列腺癌发生相关的生物标志物的安全性，合规性和评估。配制两种不同的SB，每天递送大约60mg糖苷配基当量的异黄酮。在SAB中，异黄酮作为糖苷配基（约80％作为糖苷配基）存在，而标准SB主要作为糖苷（18％总异黄酮作为糖苷配基）存在。 SB（97％±4％）和SAB（92％±18％）的合格性优良；毒性很少，仅限于1级胃肠道投诉。 SB和SAB之间的药代动力学研究显示出适度的差异。SAB餐时血清浓度峰值时间（Tmax）明显高于某些异黄酮中的SB，而在SB餐后，AUC 0至24 h的二氢黄豆苷元和O-去甲基苯丙氨酸明显增加。使用探索性聚类分析鉴定四种异黄酮的代谢型。胰岛素样生长因子结合蛋白与大豆干预明显增加了41％（P = 0.024）。本研究的结果提供了研究异黄酮代谢表型的必要框架，作为使用膳食大豆可能有益于或显示抗癌预防策略的个体的鉴定策略。用于未来大规模随机临床试验影响人前列腺癌发生的标准化SB是可行的。