International Urology and Nephrology, 2015, 47(6):965-70.

Plasma genistein and risk of prostate cancer in Chinese population

Yishuo Wu, Limin Zhang, Rong Na, et al

Department of Urology, Huashan Hospital, Fudan University, Shanghai, China; Urology Research Center, Fudan University, Shanghai, China; Shanghai Medical College, Fudan University, Shanghai, China

OBJECTIVES:

Genistein is one of the main soy isoflavones in our daily diet. There were studies proving that high-dietary intake of genistein may relate to the low morbidity and mortality of prostate cancer (PCa) in the Asian population. Since there were few studies of plasma genistein level in the Chinese population, we performed this study to preliminarily evaluate the associations among plasma genistein, epidemiologic factors and PCa in a Chinese population.

METHODS:

Between 2012 and 2013, 100 men over the age of 40 underwent prostate biopsy for PCa at Huashan Hospital, Shanghai, China. Clinical information, epidemiologic information and blood samples were collected prior to biopsy for each patient. All patients underwent 10-core ultrasound-guided transperineal prostate biopsy, and the pathology results were collected after biopsy. We measured the plasma genistein concentration of the blood samples and analyzed the results along with the clinical and epidemiologic information.

RESULTS:

Among the 100 patients, 46 (46.0 %) were diagnosed with PCa. The median plasma genistein concentration of non-PCa patients (728.6 ng/ml) was significantly higher than that of PCa patients (513.0 ng/ml) (P < 0.05). In the univariate analysis, we found that age and smoking history were related to PCa (P < 0.05). In the multivariate analysis, we found that age, smoking history and plasma genistein were related to PCa (P < 0.05). The age-adjusted odds ratio of PCa risk comparing plasma genistein level above median to that below median was 0.31 (95 % CI 0.13-0.71).

CONCLUSION:

Our study suggested that high concentration of plasma genistein level may contribute to the low incidence of prostate cancer in Chinese population.

荷兰《国际泌尿外科和肾脏病学》，2015年6月

中国人血浆金雀异黄素和前列腺癌的风险

吴一硕，张丽敏，那蓉，等

中国上海复旦大学华山医院泌尿外科; 复旦大学泌尿外科研究中心，; 复旦大学上海医学院

目的：

金雀异黄素是我们日常饮食中主要的大豆异黄酮之一。 有研究证明，高摄入量的金雀异黄素可能与亚洲人口前列腺癌（PCa）的发病率和死亡率相关。 由于中国人群血浆金雀异黄素水平的研究很少，我们进行了这项研究，初步评估了中国人群血浆金雀异黄素，流行病学因素和PCa之间的关系。

方法：

2012年至2013年间，中国上海华山医院PCA的100例40岁以上男性患有前列腺癌。在活组织检查前收集每名患者的临床资料，流行病学信息和血液样本。 所有患者均接受10核超声引导的前列腺活检，在活检后收集病理结果。 我们测量了血液样品的血浆金雀异黄素浓度，并结合临床和流行病学资料进行了分析。

结果：

在100例患者中，46例（46.0％）被诊断为PCa。 非PCa患者（728.6 ng / ml）血浆金雀异黄素浓度的中位数显著高于PCa患者（513.0 ng / ml）（P <0.05）。 在单变量分析中，我们发现年龄和吸烟史与PCa相关（P <0.05）。 在多变量分析中，我们发现年龄，吸烟史和血浆金雀异黄素与PCa相关（P <0.05）。 比较血浆金雀异黄素水平高于中位数的PCa风险的年龄调整优势比为0.31（95％CI 0.13-0.71）。

结论：

我们的研究表明，高浓度的血浆金雀异黄素水平可能有助于中国人群前列腺癌的发生率降低。