Andrology, 2016, 4(4):745-756.

Is phytoestrogen intake associated with decreased risk of prostate cancer? A systematic review of epidemiological studies based on 17,546 cases

M Zhang, K Wang, L Chen, et al

Department of Urology, Shengjing Hospital, China Medical University, Shenyang, China

This study uses current epidemiological data to evaluate whether phytoestrogen intake is associated with a reduced risk of prostate cancer. We performed a random-effect meta-analysis of published data retrieved from PubMed, Web of Science, ProQuest, and CNKI, which was supplemented by a manual search of relevant references. Study quality was assessed using the Newcastle–Ottawa Scale (NOS). Subgroup analysis and meta-regression were performed to explore the source of heterogeneity. Sensitivity analysis was evaluated to assess the stability of the results. Egger's test and funnel plots were used to detect the existence of publication bias. We retrieved 507 papers, and 29 studies were ultimately confirmed as eligible. The meta-analysis showed that phytoestrogen intake was significantly associated with a reduced risk of prostate cancer, with an odds ratio (OR) of 0.77 (95% CI 0.66–0.88; I2 = 77.6%). The food/nutritional sources that were significantly associated with a reduced risk of prostate cancer included soy and soy products, tofu, legumes, daidzein, and genistein. Subgroup analysis indicated that the associations were significant among Asians and Caucasians, but not among Africans. Meta-regression revealed that the pooled OR increased with the number of cases in the studies. The results might be affected by publication bias based on the Eggers’ test (p = 0.011) and the asymmetry of the funnel plot. Phytoestrogen intake may reduce the risk of prostate cancer in Asians and Caucasians. Regular intake of food that is rich in phytoestrogens, such as soy/soy products or legumes, should be recommended.

英国《男性》, 2016, 4(4):745-756.

基于17,546例流行病学研究的系统综述，植物雌激素摄入与前列腺癌的风险降低有关吗？

张m，王k，陈l等

中国医科大学附属盛京医院泌尿外科，沉阳

本研究使用当前流行病学数据来评估植物雌激素摄入是否与前列腺癌的风险降低相关。我们对从PubMed，Web of Science，ProQuest和CNKI检索的已发表数据进行了随机效应荟萃分析，并辅以相关参考文献的手动检索。使用Newcastle-Ottawa Scale（NOS）评估研究质量。进行亚组分析和meta回归以探究异质性的来源。评价灵敏度分析以评价结果的稳定性。使用Egger's检验和漏斗图检测出版偏倚的存在。我们检索了507篇论文，29篇研究最终被确认为合格。荟萃分析显示植物雌激素摄入与前列腺癌风险降低显着相关，OR为0.77（95％CI 0.66-0.88; I2 = 77.6％）。与前列腺癌风险降低显着相关的食物/营养来源包括大豆和豆制品，豆腐，豆类，黄豆苷原和染料木素。亚组分析表明，亚洲和白种人之间的关联是显着的，而不是非洲人。 Meta回归显示，合并的OR随着研究中的病例数增加。结果可能受到基于Eggers检验（p = 0.011）的出版偏倚和漏斗图的不对称性的影响。植物雌激素摄入可以降低亚洲人和白种人中前列腺癌的风险。应建议定期摄入富含植物雌激素的食物，如大豆/豆制品或豆类。