Current Pharmacology Reports, 2016, 2(1):11-20.

Natural Agents Used in Chemoprevention of Aerodigestive and GI Cancers

Jay Morris, Yuan Fang, Keya De Mukhopdhyay, et al

Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229

Aerodigestive cancers are on an increasing level in both occurrence and mortality. A major cause in many of these cancers is disruption of the inflammatory pathway, leading to increased cell proliferation, and epigenetic silencing of normal regulatory genes. Here we review the research on several natural products: silibinin, silymarin, quercetin, neem & nimbolide, gingerol, epigallatecatechin-3- gallate, curcumin, genistein and resveratrol conducted on aerodigestive cancers. These types of cancers are primarily those from oral cavity, esophagus/windpipe, stomach, small and large intestine, colon/rectum and bile/pancreas tissues. We report on the utilization in vivo and in vitro systems to research these dose effects on the inflammatory and epigenetic pathway components within the aerodigestive cancer. To follow up on the basic research we will discuss remaining research questions and future directions involving these natural products as putative stand alone or in combination with clinical agents.

《当前药理学杂志》, 2016, 2(1):11-20.

用于化学预防的呼吸道和胃肠道癌症的天然药物

德克萨斯大学健康科学中心分子医学系，圣安东尼奥，圣安东尼奥，德克萨斯州78229

呼吸道和消化道相关的癌症发病率和死亡率都在逐年增加。在这些癌症中的主要原因是炎症途径的破坏，导致增加的细胞增殖和正常调节基因的表观遗传沉默。在这里我们挑选了几种天然产品的研究：水飞蓟宾，水飞蓟，槲皮素，neem和nimbolide，姜辣素，epigallatecatechin-3-没食子酸，姜黄素，染料木黄酮和白藜芦醇进行呼吸癌症的研究。这些类型的癌症主要是来自口腔，食道/气管，胃，小肠和大肠，结肠/直肠和胆汁/胰腺组织。我们报告体内外系统的利用率，以研究这些剂量对炎症和表观遗传途径组件内消化道癌症中的影响。为了跟进基础研究，我们将讨论剩余研究问题和未来发展的方向，涉及这些天然产物作为单独使用或与临床试剂组合。