Biomedicine & Pharmacotherapy, 2016, 82:379-392.

Genistein as antioxidant and antibrowning agents in in vivo and in vitro: A review

Md. Anisur Rahman Mazumder, Parichat Hongsprabhas

Department of Food Technology and Rural Industries, Faculty of Agricultural Engineering and Technology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh; Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, 50 Phahonyothin Road, Chatuchak, Bangkok 10900, Thailand

Genistein is a phytoestrogen with diverse biological activities. It is a potent antioxidant and antibrowning agent in in vivo and in vitro. Genistein acts as a preventative and therapeutic effects for cancers, postmenopausal syndrome, osteoporosis and cardiovascular diseases in animals and humans. Gensitein possesses cancer related enzyme-inhibitory effect and substantially inhibits skin carcinogenesis and cutaneous aging induced by ultraviolet (UV) light in mice and photodamage in humans. Two-stage skin carcinogenesis showed genistein exhibited a moderate inhibition of ornithine decarboxylase activity through blockage of DNA adducts formation. The anticancer, anti-inflammatory, cardio-protective and enzyme-inhibitory effects of genistein might be related to their antioxidant activities. Genistein also altered the Maillard reaction pathway by trapping the advanced glycation end products (AGEs) both in biological and protein-lactose suspensions. As a result, soy isoflavone can be used to enrich or fortify different types of food products.

法国《生物医学与药物治疗》, 2016, 82:379-392.

染料木黄酮在体内外作为抗氧化剂和抗褐变剂的综述

马里兰州尼斯 · 拉赫曼 Mazumder，Parichat Hongsprabhas

食品部门技术和农村工业，学院中国农业大学农业工程与技术、 孟加拉国、 沁 2202年、 孟加拉国;部的食品科学和技术、 农产工业、 农业大学、 50 Phahonyothin 路、 乍都乍、 泰国曼谷 10900 系

染料木黄酮是一种具有多种生物活性的植物雌激素。它在体内外具有强效的抗氧化性和抗褐变性。染料木黄酮作为动物及人类预防和治疗癌症、 更年期综合征、骨质疏松症和心血管疾病。Gensitein 具有癌症相关酶抑制作用，极大地抑制皮肤癌变和紫外线 (UV) 对老鼠和人类的皮肤引起的老化问题。两阶段皮肤癌变表明染料木黄酮通过堵塞的 DNA 加合物形成具有适度抑制的鸟氨酸脱羧酶活性。染料木黄酮的抗肿瘤、 抗炎、 心脏保护和酶抑制影响可能与它们的抗氧化活动有关。染料木黄酮还通过捕获晚期的糖化终产物 (AGEs) 这两个生物和蛋白质乳糖的悬浮液中改变的美拉德反应途径。因此，大豆异黄酮可以用于丰富或强化不同类型的食品产品。