Expert Review of Hematology, 2015, 8(4):1-10.

Potential pharmacological interventions against hematotoxicity: an overview

Pooja Shukla, Rama Singh

Academy for Scientific and Innovative Research, New Delhi 110 001, India

Various treatment regimens, including chemotherapy, are known to induce heavy oxidative stress on the system, which in turn leads to adverse effects on healthy tissues. Blood being prone to oxidative stress is affected the most. At this juncture, it might not be prudent to anticipate having chemotherapeutic agents with no hematotoxicity; the best way forward is to look for potential anti-hematotoxic compounds, which could be supplemented to exposed patients, thus reducing the toxic burden on blood cells. We mined existing literature for reviewing possible interventions against hematotoxicity and figured that there is a great lacuna in this field in terms of not having such useful information at one place. This review presents the possible entities based on their antioxidant potentials, including their mechanistic pathways.

英国《血液学专家综述》，2015年8月

对血液毒性的潜在药理性干预︰ 综述

普佳 舒克拉，拉玛 辛格

印度新德里科学和创新研究学院