Biomedicine & Pharmacotherapy, 2015, 76:30-38.

Bioactivity of genistein: A review of in vitro and in vivo studies

Ajaz Ahmad Ganai, Humaira Farooqi

epartment of Biotechnology, Faculty of Science, Jamia Hamdard, New Delhi 110062, India

Genistein is a soy derived isoflavanoid compound with multitude of health benefits. This compound is found to be a potent agent in both prophylaxis and treatment of cancer and various other chronic diseases. Ranging from its antioxidant activity to its effect on various cancer types, genistein has been a compound of interest in a number of studies carried out so far. The great interest that has focused on genistein led to the identification of numerous intracellular targets of its action in the live cells. Retardation of atherogenic activity and increasing the antioxidant defense of a cell has been attributed to genistein while as it has also been reported that genistein possesses suppressive effects on both the cell-mediated and humoral components of the adaptive immune system. At the molecular level, genistein reduces the number of developing CD4(+) and CD8(+) thymocytes suggesting a possible mechanism for genistein effects on cell-mediated immunity. Genistein may inhibit cancer progression by inducing apoptosis or inhibiting proliferation. In addition, genistein has its prominent role in preventing the DNA damage. Apolipoprotein B secretion gets reduced when the subjects are administered with genistein. Genistein confers a better protection to ischemic conditions thereby giving a significant cardioprotection. At cellular level adipocyte differentiation is another property of genistein which makes it a better neutraceutical which can reduce the atherogenic condition and hypercholesterolemia. Expression of human endothelial nitric oxide synthase is associated with genistein supplementation. The advantage of using genistein is its multidirectional action and its lesser toxicity.

法国《生物医学与药物治疗》，2015年12月

金雀异黄素的生物活性︰ 体外和体内研究的综述

埃杰克斯 艾哈迈德 格耐，呼麦尔 法鲁齐

印度新德里科学院生物技术部

金雀异黄素是一种大豆衍生的异黄酮化合物，具有很多保健优点。这种化合物被发现具有强效的预防和治疗癌症和其他各种慢性疾病的潜力。从其抗氧化活性及其对各种癌症类型的影响，到目前为止金雀异黄素已经成为多项研究的兴趣所在。最大的兴趣集中在金雀异黄素在存活细胞中发挥作用时的诸多细胞内靶标。动脉粥样硬化活性的迟缓，以及提高细胞的抗氧化防护能力可以归功于金雀异黄素，同时金雀异黄素还被报道对于适应性免疫系统的细胞免疫及体液成分具有抑制作用。在分子水平上，金雀异黄素减少了 CD4(+) 和 CD8 （+） 胸腺细胞的发展数量，表明金雀异黄素对细胞调节的免疫功能影响的可能机制。金雀异黄素可能通过诱导细胞凋亡和抑制增殖抑制癌症的进展。此外，金雀异黄素在防护 DNA 损伤方面有突出的作用。当受试者服用金雀异黄素时载脂蛋白 B 的分泌物减少。金雀异黄素为缺血条件提供了更好的保护从而赋予了重要的心脏保护作用。在细胞水平的脂肪细胞的分化是金雀异黄素的另一个属性可以使其更好的减少动脉粥样硬化条件和高胆固醇血症。人体内皮细胞一氧化氮合酶的表达与金雀异黄素补充剂相关。使用金雀异黄素的优点是其多方向的活动和较低的毒性。