Cardiovascular & Hematological Agents in Medicinal Chemistry, 2011, 9(2):62-77.

Anticancer Properties of Flavonoids: Roles in Various Stages of Carcinogenesis

Nicolas Clere, Sébastien Faure, Maria Carmen Martinez, et al

INSERM UMR U694, Université d'Angers, Angers, France

High dietary intake of fruits and vegetables is consistently associated with a reduced risk of common human cancers. The specific mechanisms of action of most phytochemicals in cancer prevention are not yet clear but appear to be varied. One class of compounds currently under investigation is flavonoids, a large group of molecules with similar structure. Although their bioavailability is discussed, numerous in vitro and animal model data suggest that flavonoids modulate important cellular and molecular mechanisms related to carcinogenesis, a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor cells. Epidemiological studies confirmed that, among many flavonoids, apigenin, epigallocatechin gallate, delphinidin and genistein appear to be beneficial compounds in various stages of carcinogenesis. Therefore, according to in vitro and in vivo studies, this review attempts to increase our understanding about the preventive and therapeutic effects of these compounds to facilitate extrapolation of results from animal studies to human situations.

荷兰《医药化学之心血管及血液学药剂》，2011年4月

黄酮类化合物的抗癌特性︰ 在癌变过程中各个阶段的作用

尼古拉斯  克莱雷，塞巴斯蒂安 福瑞，玛丽亚卡门  马丁内斯等

法国昂热大学

高膳食摄入量的水果和蔬菜通常与普通人类癌症的风险降低有关。大多数植物在癌症预防方面的具体机制虽不明确却呈现多元化的趋势。目前正在研究的一类化合物是黄酮类化合物，一种具有相似结构的分子。