International Journal of Molecular Sciences, 2015, 16(5):11728-11749.

Soy and Breast Cancer: Focus on Angiogenesis

Lenka Varinska, Peter Gal, Gabriela Mojzisova, et al

Department of Pharmacology, P.J. Šafárik University, Faculty of Medicine, Trieda SNP 1, 040 11 Košice, Slovakia; et al

Epidemiological studies have revealed that high consumption of soy products is associated with low incidences of hormone-dependent cancers, including breast and prostate cancer. Soybeans contain large amounts of isoflavones, such as the genistein and daidzain. Previously, it has been demonstrated that genistein, one of the predominant soy isoflavones, can inhibit several steps involved in carcinogenesis. It is suggested that genistein possesses pleiotropic molecular mechanisms of action including inhibition of tyrosine kinases, DNA topoisomerase II, 5α-reductase, galectin-induced G2/M arrest, protein histidine kinase, and cyclin-dependent kinases, modulation of different signaling pathways associated with the growth of cancer cells (e.g., NF-κB, Akt, MAPK), etc. Moreover, genistein is also a potent inhibitor of angiogenesis. Uncontrolled angiogenesis is considered as a key step in cancer growth, invasion, and metastasis. Genistein was found to inhibit angiogenesis through regulation of multiple pathways, such as regulation of VEGF, MMPs, EGFR expressions and NF-κB, PI3-K/Akt, ERK1/2 signaling pathways, thereby causing strong antiangiogenic effects. This review focuses on the antiangiogenic properties of soy isoflavonoids and examines their possible underlying mechanisms.

《国际分子科学杂志》，2015年5月

大豆和乳腺癌︰ 关注血管生成

兰卡 沃瑞斯卡，彼得 加仑，加芙列拉 摩扎斯威亚，等

斯洛伐克考门斯基大学医学院药理学系等

流行病学研究表明，大豆产品的高消耗与包括乳腺癌和前列腺癌等荷尔蒙相关癌症的低发病率有关。大豆含有大量异黄酮，例如金雀异黄素和 大豆苷元 。先前，已经证明金雀异黄素，一种主要的大豆异黄酮，可以抑制癌变过程所涉及的几个步骤。这说明金雀异黄素具有多效的分子机制包括抑制酪氨酸激酶、 DNA 拓扑异构酶 II、 5 α-还原酶、 半乳糖凝集素诱导的 G2/M 期阻滞、 蛋白质组氨酸激酶和细胞周期蛋白依赖性的激酶，不同信号通路的调节与肿瘤细胞的生长相关 (如，NF-κB，Akt，MAPK) 等。此外，金雀异黄素也是一种有效的血管生成抑制剂。不受控制的血管生成被认为是肿瘤生长、 侵袭及转移的关键一步。金雀异黄素被发现可以通过多种途径抑制血管生成，例如调节 VEGF，MMPs，EGFR 表达和 NF-κB、 PI3-K/Akt，ERK1/2 信号通路，从而造成较强的抗血管生成的作用。本综述关注大豆异黄酮的抗血管生成属性，并探讨其可能的作用机制。