Pancreas, 2015, 44(1):11-15.

Potential New Pharmacological Agents Derived From Medicinal Plants for the Treatment of Pancreatic Cancer

Haniye Azimi, Ali Asghar Khakshur, Mohammad Abdollahi, et al

Faculty of Pharmacy, Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center; Faculty of Traditional Medicine, Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

In the present article, we reviewed plants and phytochemical compounds demonstrating beneficial effects in pancreatic cancer to find new sources of pharmaceutical agents. For this purpose, Scopus, PubMed, Web of Science, and Google scholar were searched for plants or herbal components with beneficial effects in the treatment of pancreatic cancer. Data were collected up to January 2013. The search terms were "plant," "herb," "herbal therapy," or "phytotherapy" and "pancreatic cancer" or "pancreas." All of the human in vivo and in vitro studies were included. According to studies, among diverse plants and phytochemicals, 12 compounds including apigenin, genistein, quercetin, resveratrol, epigallocatechin gallate, benzyl isothiocyanate, sulforaphane, curcumin, thymoquinone, dihydroartemisinin, cucurbitacin B, and perillyl alcohol have beneficial action against pancreatic cancer cells through 4 or more mechanisms. Applying their plausible synergistic effects can be an imperative approach for finding new efficient pharmacological agents in the treatment of pancreatic cancer.

美国《胰腺》，2015年1月

从药用植物衍生的潜在新型药物用于治疗胰腺癌

哈尼耶 艾思密，阿里 阿斯加尔 卡库术，穆罕默德 阿多拉奇，等

伊朗医药科学研究中心药理及毒理学学院药学系; 伊朗德黑兰医科大学学院传统医学学院传统医学系

在本文中，我们综述了植物与植物化学成分化合物在胰腺癌中表现出的有益作用，寻找新的药物制剂来源。为此目的，在Scopus、PubMed、Web of Science 和谷歌学术中搜索对治疗胰腺癌有益的植物或中药组分。数据收集到 2013 年 1 月。搜索词是"植物"、"草药"、"草药疗法"或"植物疗法"和"胰腺癌"或"胰腺”。所有人体的体内和体外研究都包括在内。研究表明，在多种植物和植物化学物质中， 12 种化合物包括芹菜、 金雀异黄素、 槲皮素、 白藜芦醇、 儿茶素没食子酸，苄基异硫氰酸酯、 莱菔硫烷、 姜黄素、百里香醌、 双氢青蒿素、 葫芦素 B 和紫苏醇通过 4 种或更多的机制拥有对胰腺癌细胞有益的疗效。在胰腺癌的治疗过程中应用合理的协同效应可以寻找新的高效药剂。