Analytical Cellular Pathology, 2015, 2015:1-8.

Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation

Corina Danciu, Codruta Soica, Cristina Dehelean, et al

Department of Pharmacognosy, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania; et al

The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity. Cytotoxic effects were measured in vitro on three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma). The in vitro biological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines, behavior that may be due to the high stability of the complex within the in vitro environment.

荷兰《细胞病理学分析》，2015年5月

酯化反应和环糊精封装的金雀异黄素化学预防能力的体外初级评价

科瑞娜 丹秀，克里斯蒂娜 德黑兰，等

罗马尼亚维克托医药大学生药学学院等

本研究集中于一种金雀异黄素与肉豆蔻酸的酯衍生物然后用β 环糊精封装的合成和分析；使用先进技术进行理化分析，如红外光谱、 质谱、 DSC 法和SEM等来揭示酯化和环糊精包合的成功。测定三种人体细胞的体外细胞毒性作用︰ HeLa （宫颈腺癌）、 A2780 （卵巢癌），和 A431 （皮肤表皮癌）。体外生物分析表明所有三种测试癌细胞较差的抗增殖活性，可能是由于其在体外复杂环境中的稳定性。